In 2016, The Jackson Laboratory (JAX), a National Cancer Institute-designated Cancer Center and at the forefront of cancer research, launched the Maine Cancer Genomics Initiative (MCGI) to bring the latest progress in cancer care to rural Maine patients. Now, after successfully expanding access to genome tumor testing and targeted cancer treatments throughout Maine, the MCGI team provides compelling evidence that genome-matched treatments can provide significant patient benefit.
The MCGI report, published recently in npj Precision Oncology, presents data showing that only 17% of patients received genome-matched treatment through MCGI, signaling a large gap between testing and delivery of treatment based on genomic information. However, those who did receive genome-matched treatment were 31% less likely to die within one year compared to those who did not receive matched treatment. While this is an observational study, the findings clearly point to the potential for a significant one-year survival benefit from genomic tumor testing and matched treatments.
In this observational study, there were many reasons why cancer patients didn't receive genome-matched treatments after the program sequenced the tumor's DNA. A certain percentage of patients did not have an actionable tumor variant detected, so they received standard of care.
"For the rest, it was a matter of care delivery," said Jens Rueter, M.D., chief medical officer of JAX and medical director of MCGI. "Patients may have had an actionable tumor variant but only through participation in a clinical trial that isn't available in rural Maine, or a patient's community hospital may not have been able to deliver a treatment that's already on the market."
Spearheaded by Rueter, who is also associate director for translational education at JAX Cancer Center and Edison Liu, M.D., former JAX President and CEO., the impetus for launching MCGI in 2016 was the lack of local access to recently developed genomic testing and targeted therapy strategies for cancer patients in Maine. In addition, most patients lacked the time and means to travel to Boston or New York for care. Therefore, JAX created MCGI to bring the latest technology in precision oncology and treatment to patients.
In only four years, through 2020, MCGI had partnered with every oncology practice in Maine (there are 13 of them) and enrolled more than 1,600 of their patients. Leah Graham, program director of MCGI, described that early work focused on providing genomic education to oncologists and other healthcare professionals, free access to genomic tumor testing for their patients, and detailed consultation about test results with precision oncology experts through a genomic tumor board.
