Osaka-Japan - We all know someone who seems to defy aging—people who look younger than their peers despite being the same age. What's their secret? Scientists at Osaka University (Japan) may have found a way to quantify this difference. By incorporating hormone (steroid) metabolism pathways into an AI-driven model, they have developed a new system to estimate a person's biological age a measure of how well their body has aged, rather than just counting the years since birth.
Using just five drops of blood, this new method analyzes 22 key steroids and their interactions to provide a more precise health assessment. The team's breakthrough study, published in Science Advances, offers a potential step forward in personalized health management, allowing for earlier detection of age-related health risks and tailored interventions.
Unlocking the Body's Aging Signature
Aging isn't just about the number of years we've lived—it's shaped by genetics, lifestyle, and environmental factors. Traditional methods for estimating biological age rely on broad biomarkers, such as DNA methylation or protein levels, but these approaches often overlook the intricate hormonal networks that regulate the body's internal balance.
"Our bodies rely on hormones to maintain homeostasis, so we thought, why not use these as key indicators of aging?" says Dr. Qiuyi Wang, co-first author of the study. To test this idea, the research team focused on steroid hormones, which play a crucial role in metabolism, immune function, and stress response.
A New AI-Powered Model
The team developed a deep neural network (DNN) model that incorporates steroid metabolism pathways, making it the first AI model to explicitly account for the interactions between different steroid molecules. Instead of looking at absolute steroid levels—which can vary widely between individuals—the model examines steroid ratios, providing a more personalized and accurate assessment of biological age.
"Our approach reduces the noise caused by individual steroid level differences and allows the model to focus on meaningful patterns," explains Dr. Zi Wang, co-first and corresponding author of this work. The model was trained on blood samples from hundreds of individuals, revealing that biological age differences tend to widen as people get older—an effect the researchers liken to a river widening as it flows downstream.
Key Insights and Implications
One of the study's most striking findings involves cortisol, a steroid hormone commonly associated with stress. The researchers found that when cortisol levels doubled, biological age increased by approximately 1.5 times. This suggests that chronic stress could accelerate aging at a biochemical level, reinforcing the importance of stress management in maintaining long-term health.
"Stress is often discussed in general terms, but our findings provide concrete evidence that it has a measurable impact on biological aging," says Professor Toshifumi Takao, a corresponding author and an expert in analytical chemistry and mass spectrometry.
The researchers believe this AI-powered biological age model could pave the way for more personalized health monitoring. Future applications may include early disease detection, customized wellness programs, and even lifestyle recommendations tailored to slow down aging.
Looking Ahead
While the study represents a significant step forward, the team acknowledges that biological aging is a complex process influenced by many factors beyond hormones. "This is just the beginning," says Dr. Z. Wang. "By expanding our dataset and incorporating additional biological markers, we hope to refine the model further and unlock deeper insights into the mechanisms of aging."
With ongoing advancements in AI and biomedical research, the dream of accurately measuring—and even slowing—biological aging is becoming increasingly feasible. For now, though, the ability to assess one's "aging speed" with a simple blood test could mark a game-changing development in preventive healthcare.
The article, "Biological age prediction using a DNN model based on pathways of steroidogenesis," was published in Science Advances of the United States of America at DOI: https://doi.org/10.1126/sciadv.adt2624 .
About Osaka University
Osaka University was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world. Now, Osaka University is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.
Website: https://resou.osaka-u.ac.jp/en
