About The Study: Direct-mail human papillomavirus (HPV) self-sampling increased cervical cancer screening by more than 14% in individuals who were due or overdue for cervical cancer screening in this randomized clinical trial of 31,000 individuals. The opt-in approach minimally increased screening. To increase screening adherence, systems implementing HPV self-sampling should prioritize direct-mail outreach for individuals who are due or overdue for screening. For individuals with unknown screening history, testing alternative outreach approaches and additional efforts to document screening history are warranted.
Authors: Rachel L. Winer, Ph.D., M.P.H., of the University of Washington in Seattle, is the corresponding author.
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(doi:10.1001/jama.2023.21471)
