A study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.
The paper, " Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels ," appears in the Journal of Clinical Investigation.
Estrogen receptor positive breast cancer is the most common form of the disease, and cancer cells of this kind can live for years—or even decades—in bone marrow after remission.
The persistence of these cells in marrow leads to the disease recurring in a large proportion of patients (approximately 40%.)
This return can take the form of especially aggressive bone cancer with symptoms such as bone fractures and hypercalcemia.
The cells can also spread to other organs, causing recurrent disease that is currently incurable.
To better understand how these cancer cells survive, and why they cause such aggressive returning disease, researchers investigated what happens to these dispersed cells in bone marrow.
Their key finding was the mechanism by which a normal cell type, mesenchymal stem cells, in the bone marrow supports the cancer cells.
"We discovered that the breast cancer cells require direct contact with mesenchymal stem cells," said Gary Luker, M.D., head of U-M's Luker Lab within the Center for Molecular Imaging, and senior author on the paper.
"The cancer cells physically borrow molecules—proteins, messenger RNA—directly from the mesenchymal stem cells. Essentially the mesenchymal stem cells act as very generous neighbors in donating things that make the cancer cells more aggressive and drug resistant."
