The Bruce Highway between Brisbane and Traveston has re-opened for priority travel.
Drivers are reminded to only travel for essential reasons, avoid queuing on the highway and follow advisory signs.
Transport and Main Roads Minister Mark Bailey said sections of the highway in the south would operate at reduced capacity and reduced speed limits due to the weather event.
"I'm pleased to report between Brisbane and Traveston has re-opened with trucks able to get through, and families and loved ones now able to reconnect," Mr Bailey said.
"The message is still for people to only travel if necessary.
"Our crews are still working around the clock to repair parts of the Bruce, and they need time and space to get the work done, so please only travel if you absolutely need to.
"People should allow additional travel time between Brisbane and Traveston with delays expected and be on the lookout for emerging potholes after the flooding."
Mr Bailey said the highway remained closed from the Mary Valley Link Road interchange at Traveston due to significant flooding in Gympie and Maryborough.
"We understand the Bruce Highway is the lifeblood of our state and we are working as quickly as possible to re-open the section north of Mary Valley Link Road interchange at Traveston when it is safe to do so," he said.
Mr Bailey said priority inspections, repairs and maintenance would continue.
"Specialist road crews have been working to clear debris and mud from major roads and undertake vital safety inspections," he said.
"We anticipate substantial repairs will be required across the network and we thank motorists for their patience while we continue assessments and program repairs over coming months."
Motorists are urged to check the QldTraffic website before travel and make alternative arrangements where needed.
The QLD Traffic website is available at www.qldtraffic.gov.au.au or by downloading the QLDTraffic app or by calling 131940.
Queensland Police Service, traffic controllers and advisory signs are on the ground.
Please follow all signs and directions.
There are more than 50 state-controlled roads closed across the North Coast along with many other local roads.
For storm-related assistance, call the SES on 132 500 or download the SES Assistance QLD app.
In a life-threatening situation, always call triple zero (000).
