Major Collision Investigation Unit detectives are appealing for public assistance as they investigate a serious collision in Yering this afternoon.
It is believed a hatchback collided with a four-wheel drive which then hit a sedan on the Melba Highway about 3.45pm on 3 July.
The driver of the hatchback, a 21-year-old Mount Evelyn woman, was taken to hospital with serious injuries.
Her passenger, a 1-year-old boy, was airlifted to hospital with life-threatening injuries.
The sole occupant of the four-wheel drive, a 61-year-old Yarra Glen woman, sustained non-life-threatening injuries and was taken to hospital.
The sole occupant of the sedan, a 29-year-old Dandenong man, was uninjured and did not require hospitalisation.
Drivers are advised the Melba Highway will be closed in both directions for several hours while detectives investigate.
Detectives urge anyone who witnessed the collision or with dashcam footage to contact Crime Stoppers on 1800 333 000 or file a confidential report online at www.crimestoppersvic.com.au