A new database covering over 100 different canine tissues can significantly enhance our understanding of hereditary diseases and provide valuable information for health research in both dogs and humans.
The International DoGA Consortium has achieved a significant milestone in genetics research by creating a comprehensive canine promoter and gene expression atlas. The atlas is a database that shows which genes are active in different parts of the body and when they are activated. This helps researchers better understand how genes function in various situations and how they impact health and diseases.
An important tool for the scientific community studying genetic diseases
"This new international database is a significant advancement for genetic disease researchers, not only for dogs but also for other species. Our comprehensive database provides a crucial resource for understanding gene regulation and will serve as a critical tool for the scientific community for years to come," says Professor Hannes Lohi, one of the lead researchers of the study from the Faculty of Veterinary Medicine and Medicine at the University of Helsinki.
The creation of the DoGA atlas was the result of close collaboration among researchers worldwide. The project involved experts in genomics, veterinary medicine, and computational biology. Researchers collected over 5,000 samples from various dog breeds and wolves, using advanced RNA sequencing techniques to map gene expression and promoter structures. This extensive work significantly improves the canine gene map compared to other model organisms such as mice, zebrafish, or cattle.
A versatile resource for future medical research
"We created a research resource that significantly enhances the use of dogs as a model for human health research, as well as directly for studying canine genetics. We demonstrated the potential of the database with several examples for different research purposes, such as comparing changes during embryonic development, the expression of disease genes in various tissues, and the regulation of genes related to behavioral traits," explains PhD Matthias Hörtenhuber, one of the leading authors of the article from Karolinska Insitutet, Stockholm.
The open DoGA database provides the scientific community with an interactive gene atlas, allowing researchers to comprehensively study gene expression in different tissues. This enables the prioritization of hereditary factors related to diseases and promotes research between humans and dogs. The data collected in the database can be used to map genes associated with cancers, epilepsy, and psychiatric disorders.
"By improving our understanding of gene regulation in both dogs and wolves, the DoGA database is expected to have a significant impact on both veterinary and human medicine. For example, we can investigate how much the brains of dogs and wolves differ from each other. Additionally, the unique genetic history and breed structures of dogs, combined with the new functional gene map, provide an effective framework for studying genetic diseases," summarizes Lohi.
Original article:
Hörtenhuber, M., Hytönen, M.K., Mukarram, A.K., Arumilli, M., Araujo, C., Quintero, I., Syrjä, P., Airas, N., Kaukonen, M., Kyöstilä, K., Niskanen, J., Jokinen, T.S., Takan, I., Mottaghitalab, F., Salokorpi, N., Raman, A., Stevens, I., Iivanainen, A., Yoshihara, M., Gusev, O., Bannasch, D., Sukura, A., Schoenebeck, J., DoGA Consortium, Ezer, S., Katayama, S., Daub, C.O., Kere, J., Lohi, H. (2024). The DoGA consortium expression atlas of promoters and genes in 100 canine tissues. Nature Communications. https://doi.org/10.1038/s41467-024-52798-1
DoGA-Consortium
The Dog Genome Annotation (DoGA) Consortium is a collaborative project led by Professors Hannes Lohi, Juha Kere, and Carsten Daub, involving experts from multiple universities worldwide. The primary funding for the project has been provided by the Jane and Aatos Erkko Foundation.
