Heitor Medeiros, MD, and A. Sassan Sabouri , MD, of the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital, are the lead and corresponding authors, respectively, of a paper published in the British Journal of Anaesthesia (BJA) .
How would you summarize your study?
Spinal anesthesia is widely used to numb patients during surgery, but its effects sometimes wear off too soon. Many anesthetists have experimented with adding extra drugs to extend pain relief. Dexmedetomidine demonstrated results in multiple randomized clinical trials suggesting it could prolong numbness and reduce discomfort. However, the research was mixed and sometimes outdated, leaving uncertainties about its true benefits and risks.
This gap in clear evidence motivated us to conduct a systematic review and meta-analysis, aiming to combine all available data to provide safer, more effective guidance for the drug's use in clinical practice. We reviewed randomized clinical trials to see if adding dexmedetomidine to spinal anesthesia could improve its effects.
What question were you investigating?
We wanted to know if adding dexmedetomidine to spinal anesthesia could make the numbness and pain relief last longer and reduce shivering during surgery.
What approach did you use?
To do this, we reviewed and combined data from many high-quality trials comparing standard spinal anesthesia with and without dexmedetomidine.
What did you find?
We found that combining dexmedetomidine with the usual anesthetic prolonged the duration of numbness and pain relief during surgery, and it reduced shivering. However, it may slightly increase the risk of a slower heart rate.
What are the implications?
Clinically, these results suggest that patients may experience longer-lasting pain relief and fewer shivering episodes, which could lead to a smoother recovery. However, doctors should monitor heart rate closely.
What are the next steps?
The next steps involve more standardized studies to pinpoint the best dose.
Authorship: In addition to Medeiros and Sabouri, Mass General Brigham authors include Elizabeth Korn and Ariel Mueller. Other authors include Sara Amaral, Rafael A. Lombardi, Lucas P. Trevisan, Hugo W. Araújo, and Wallace Andrino.
Paper cited: Medeiros H, et al. "Effects of combined intrathecal dexmedetomidine and local anaesthetic on analgesia duration of spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials" BJA DOI: 10.1016/j.bja.2025.02.022
Funding: None
Disclosures: None
