Every mother wants to have the healthiest child she can, and new research shows that the nutritional status of the mother during pregnancy can affect outcomes for the baby - with male and female offspring affected differently.
Dr Emily Camm showed that achieving and maintaining optimal nutritional status, fitness and weight before and during pregnancy has immediate and long-term benefits for the health of both the mother and her child.
The latest work by the team from Hudson Institute of Medical Research and Cambridge University is published in the journal Nutrients, outlining research in a preclinical model that is relevant to humans.
Dr Camm said her research focused on the effects on pregnancy and offspring outcomes of a diet high in fat and sugar, and compared the results to a cohort fed a diet high in nutrients and low in sugar and saturated fats.
How does a cafeteria-style diet affect pregnancy?
"It's not always possible for women to control their body weight, but they do have control over what and how they eat, so this study aimed to show how a western "cafeteria-style" diet can impact the eventual health of the child," Dr Camm said.
"Our study focused not only on pregnancy but the pre-conception period, as this a sensitive period of development and can also have a significant impact on offspring health."
"It's important to note that pre-conception health is important for fathers as well as mothers, because an altered diet can also affect sperm quality."
"Overall, our findings demonstrate that a diet high in fats and sugar- which is very common in western and eastern societies – alters the growth, adiposity (percentage of body fat), and behaviour of offspring, but interestingly, there are sex-specific differences in the effects we found."
Girls and boys affected differently by maternal diet
After weaning there were differences in the growth rate and total body fat content of male but not female offspring who were exposed to the altered maternal diet.
"There are sex-specific differences in the way males and females respond to an altered maternal diet," Dr Camm said.
"Although the females gained more weight, at the end of the study at four months of age, the males actually had more adipose tissue (fat deposits) than the females."
The researchers also found behavioural differences in the offspring who were exposed to the altered maternal diet that continued as they grew, including more risk-taking behaviours.
"This finding is in contrast to previous studies that reported more anxiety-related behaviours in offspring whose mothers were exposed to an altered diet during the pre-conception period and/or pregnancy, but the difference is that those studies tended to use diets just high in fats, rather than both fats and sugars, which is more indicative of the diets modern western and eastern populations consume."
Next steps
Dr Camm and her team at Hudson Institute are now also studying human pregnancies - examining the placentas of women who have a high BMI, or who have experienced a pregnancy complication.
"We're trying to understand how the mum and the baby are affected in various pregnancy complications. We can get a lot of that information from the mum's blood, the placenta and the cord blood at the time of delivery," she said.
"The end goal is to work out ways in which we can intervene and help mothers have a safe pregnancy, and babies the best start to life."
