An EgyptAir flight carrying at least 59 passengers and 10 crew members went off the radar after departing from Paris and heading to Cairo, the airline said in a brief statement.
"An informed source at EGYPTAIR stated that Flight No. MS804, which departed Paris at 23:09 (CEST), heading to Cairo has disappeared from radar," the airline said on its Twitter.
Flight MS804 left Charles de Gaulle Airport at 11:09 pm on Wednesday Paris time and was expected to arrive in Cairo by 3 am on Thursday. A direct flight usually takes just over four hours.
The Egyptian government has released no comment on the incident so far.
EgyptAir tweeted out that the flight disappeared from radar at 2:45 am Cairo time, when the plane was at an altitude of 37,000 feet (11,300 meters) and around 10 miles (16 kilometers) inside Egyptian airspace.
EgyptAir confirmed that all authorities have been informed of the missing plane, which disappeared near Greece. Rescue efforts are underway.
Egyptian rescue teams are reportedly working with their Greek counterparts to locate the plane. (RT)