The Forensic Crash Unit is investigating following a fatal crash at Mount Coot-Tha this morning, August 4.
Initial investigations indicate just after 10.30am, a bicycle was travelling east along Sir Samuel Griffith Drive when it collided with a motorbike travelling in the opposite direction.
The cyclist, a 65-year-old Killarney man, was declared deceased at the scene.
The motorbike rider, a 35-year-old Fairfield man, was transported to the Royal Brisbane and Women's Hospital in a serious condition.
Anyone who witnessed the crash, or has further information, is urged to contact police.
Investigations are continuing.
If you have information for police, contact Policelink by providing information using the online suspicious activity form 24hrs per day at www.police.qld.gov.au/reporting or call 131 444.
Report crime information anonymously via Crime Stoppers. Call 1800 333 000 or report online at www.crimestoppersqld.com.au.