Entries are now open for the 2020 Drummond Real Estate Lake Hume Cycle Challenge.
The charity event to be held on Saturday, February 22 will feature four rides ranging from 5km to 126km.
This includes the popular 126km Granya Grind, known for its gruelling trek to the top of Mt Granya and breathtaking views over Lake Hume.
Other road rides will be the 32km Weir Wonder and 79km Sandy Creek course, which also take in Lake Hume as well as undulating hills, attractive farmlands and river flats.
Ranging from 5km to 25km, the family river ride will follow sealed paths on Gateway Island and through Noreuil Park.
The event is organised by the Rotary Club of Bellbridge Lake Hume and raises money for the Albury Wodonga Regional Cancer Centre Trust Fund and Border Trust.
Among the hundreds of riders expected to sign up for the Sandy Creek challenge will be former breast care nurse and Brave Hearts on the Murray president, Jenny Black.
This will be Mrs Black's fourth time taking part in the challenge, which have seen her ride the mid-range courses as well as the family ride with her six-year-old granddaughter.
"The Lake Hume Cycle Challenge gives you a special sense of achievement, riding for individuals in our community affected by a cancer diagnosis," she said.
"It certainly gives you that extra energy and reason to climb those hills.
"The other incentive to participate in this great community venture is that the money raised will go towards our regional cancer centre trust fund, the mission of which is to raise funds to support our special regional cancer centre to provide excellent cancer care and support to people in our region whose lives have been touched by a cancer diagnosis.
"We are so fortunate to be living in our regional area where our community is so willing to work together for such a great cause."
All road rides will start and finish at the Wodonga Racecourse, where there will be a chill zone with food, drink and entertainment.
For the first time in 2020, the family river ride will start and finish at Belvoir Park to take advantage of the meandering paved off-road paths in the shade along the Murray River.
There will be activities along the path, and a rider education course and face painting at the start and finish line at Belvoir Park.
Participants will also be encouraged to come dressed as their favourite super hero and be in the running for some great prizes.
The Lake Hume Cycle Challenge has raised more than $150,000 for the cancer centre trust fund and has gone towards the Wellness Centre, which provides a range of wellness and supportive care programs to patients and their families at the cancer centre.