HMS Diamond will take over from HMS Richmond, which joined Operation Prosperity Guardian - the international coalition to protect commercial shipping from Houthi attacks - in February.
Just this weekend, HMS Richmond successfully repelled a Houthi drone attack in the southern Red Sea, shooting down two attack drones using Sea Ceptor missiles. This is the first time a UK warship has fired a Sea Ceptor missile in combat.
The deployment is part of the UK's broader response to Houthi attacks, which has also included intercepting weapon-smuggling to Yemen, imposing sanctions to hold members of the Houthis to account and conducting proportionate and targeted strikes against Houthi military targets in Yemen.
Defence Secretary Grant Shapps said:
Protecting shipping around the world is one of the Navy's key tasks and this deployment shows how our highly skilled sailors and advanced warships are helping to keep our sea lanes safe.
Britain continues to be at the forefront of the international response to the Houthis' dangerous attacks on commercial vessels, which have claimed the lives of international mariners.
I thank the crew of HMS Richmond for their incredible work and am confident that HMS Diamond will continue to stand up for freedom of navigation and the safety of seafarers.
HMS Richmond, which left Plymouth at the beginning of January, is designed for a variety of operations and is fitted with a Sea Ceptor missile system, providing a powerful shield against airborne threats, including hostile combat jets, helicopters and other missiles. After handing over to HMS Diamond, she will return to the UK via Saudi Arabia for a period of maintenance and resupply.
HMS Diamond previously operated in the region in December and January, maintaining a near constant presence in the 'high threat area' of the Red Sea. The destroyer came under fire in three separate attacks Houthi rebels, successfully destroying nine drones using her world-class Sea Viper missile system and guns.
HMS Diamond has sailed nearly 20,000 nautical miles on patrols since leaving Portsmouth at the end of November - almost enough to carry her around the globe - while her Wildcat helicopter has flown more than 53 hours of sorties over the Red Sea and Gulf of Aden making its crew the busiest in the Royal Navy.
The UK remains committed to deterring the Houthis from their indiscriminate attacks in the Red Sea and Gulf of Aden. The Houthis' illegal attacks have claimed the lives of international mariners and continue to harm the global economy and undermine the stability and security of Yemen.