"The prognosis of recurrent/metastatic SS remains poor, highlighting the need for a novel therapeutic strategy."
BUFFALO, NY- July 18, 2023 – A new case report was published in Oncotarget's Volume 14 on July 7, 2023, entitled, "Intrathoracic synovial sarcoma with BRAF V600E mutation."
Synovial sarcoma (SS) is a highly malignant mesenchymal tumor that occurs mainly in adolescents and young adults. The treatment of SS is multimodal, involving surgery, radiotherapy and chemotherapy. The overall prognosis is generally quite satisfactory in children and adolescents with localized SS at diagnosis. However, the outcome remains poor for patients who relapse, with a reported 5-year post-relapse survival of around 30%.
In this new paper, researchers Ida Russo, Sabina Barresi, Pier Luigi Di Paolo, Valentina Di Ruscio, Giada Del Baldo, Annalisa Serra, Silvia Vallese, Evelina Miele, Angela Mastronuzzi, Rita Alaggio, Andrea Ferrari, and Giuseppe Maria Milano from Italy's Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) report the case of a 15-year-old boy with intrathoracic synovial sarcoma who relapsed after standard chemotherapy, surgery and radiotherapy. The molecular analysis of the tumor identified a BRAF V600E mutation at time of progression of relapsed disease under third-line systemic treatment.
This mutation is commonly seen in melanomas and papillary thyroid cancers, but less prevalent (typically
"Our data highlight the importance of implementing molecular tests in SS patients to evaluate BRAF mutational actual incidence in these neoplasms."
Read the full report: DOI: https://doi.org/10.18632/oncotarget.28475
Correspondence to: Giuseppe Maria Milano
