Detectives from the Homicide Squad last night changed a man with murder as part of their investigation into the suspicious disappearance of Craigieburn man Adrian Romeo.
With assistance from the Special Operations Group, a 58-year-old Wallan man was arrested at an address in Wallan about 7.20pm.
He was subsequently interviewed by police and has been charged with one count of murder.
He will face Melbourne Magistrates' Court this morning.
The charge follows a search of a Brendan Road property in Greenvale yesterday which involved a range of specialist resources including Dog Squad, Major Crime Scene, the SES, AFP's specialist forensic search team and the NSW Police Force cadaver dogs.
Adrian was last seen by his family about 5.30pm on Saturday, 10 February at his home address.
The 43-year-old told his parents he was going to Greenvale to visit some associates and left the property in a gold 2004 Toyota Camry sedan.
Adrian was reported missing to police on Monday, 12 February.
He is yet to be located and the investigation remains ongoing.
Police are continuing to appeal for information in relation to the whereabouts of Adrian's gold 2004 Toyota Camry sedan, which has not been seen since his disappearance.
An image of his vehicle, as well as photos of Adrian, have also been re-released.
Detectives are appealing to anyone with information about the vehicle or Adrian's whereabouts to contact Crime Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au