Major Collision Investigation Unit detectives are investigating a fatal crash in Hawthorn East this afternoon.
It's believed a vehicle was traveling along Burgess Street just after 2.30 when the car veered off the road and crashed through a school fence.
The driver, a 40-year-old Hawthorn East woman, was arrested at the scene.
She has since been released pending further enquiries.
Her passenger, a primary school aged child, was not injured.
One boy, aged 11-years-old, was taken to hospital with critical injuries but he has since died.
Two girls aged 11-years-old, one 10-year-old girl and a 10-year-old boy were all taken to hospital with serious injuries.
The investigation remains ongoing.
Anyone who witnessed the incident, has dashcam/CCTV footage or information is urged to contact Crime Stoppers on 1800 333 000 or www.crimestoppersvic.com.au.