Miniature robots on the millimeter scale often lack the strength to transport instruments for endoscopic microsurgery through the body. Scientists at the German Cancer Research Center (DKFZ) are now combining several millimeter-sized TrainBots into one unit and equipping them with improved "feet". For the first time, the DKFZ team was able to perform an electric surgical procedure on a bile duct obstruction experimentally with a robotic convoy.
The list of conceivable applications for miniature robots in medicine is long: from targeted drug application to sensing tasks and surgical procedures. An arsenal of robots has already been developed and tested for this range of tasks, from the nanometer to the centimeter scale.
However, the little helpers available today reach their limits in many tasks. For example, in endoscopic microsurgery. The required instruments are often too heavy for a single millimeter-sized robot to carry to its destination. Another common problem is that the robots often have to move by crawling. However, the surfaces of numerous body structures are covered with mucus on which the robots slip and cannot move.
"Spikes" on the feet provide three times the propulsive force
A team led by Tian Qiu at the DKFZ in Dresden has now developed a solution for both of these problems: their TrainBot connects several individual robots on the millimeter scale. The units are equipped with improved anti-slip feet. Together, they are able to transport an endoscopic instrument. The TrainBot unit works wireless; an rotating magnetic field simultaneously controls the individual units. The magnetic control enables movements in a plane with the control of rotation. The external actuation and control system is designed for the distances at the human body scale.
Microsurgery in the bile duct
The Dresden-based DKFZ researchers have already used their robot convoy of three TrainBot units to simulate a surgical procedure. In the case of bile duct cancer, the bile duct often becomes blocked, causing bile to back up, which is a very dangerous situation for those affected. In this case, the occlusion must be opened after an endoscopic diagnosis. To do this, a flexible endoscope is inserted through the mouth into the small intestine and from there into the bile duct. One of the major difficulties here is for the endoscope to navigate around the sharp angle from the small intestine into the bile duct.
"This is where the flexible robot convoy can show its strengths," says the project leader Tian Qiu. His team demonstrated it using organs removed from a pig. The robot convoy was able to maneuver an endoscopic instrument for electrical tissue ablation in the bile duct. Once the tip of the wire electrode arrives at the site, electrical voltage is applied and a tissue blockage is gradually removed electrically, a procedure known as "electrocauterization". The wire electrode used was 25 cm long and three and a half times as heavy as a TrainBot unit. "Afterwards, for example, another TrainBot convoy can bring a catheter for fluidic drainage or drug delivery," says Moonkwang Jeong, the first author of the paper, "After the promising results with the TrainBots in the organ model, we are optimistic that we will be able to develop teams of miniature robots for further tasks in endoscopic surgery."
Publication:
Moonkwang Jeong, Xiangzhou Tan, Felix Fischer, Tian Qiu: A Convoy of Magnetic Millirobots Transports Endoscopic Instruments for Minimally-Invasive Surgery. Advanced Science 2024, https://doi.org/10.1002/advs.202308382
With more than 3,000 employees, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) is Germany's largest biomedical research institute. DKFZ scientists identify cancer risk factors, investigate how cancer progresses and develop new cancer prevention strategies. They are also developing new methods to diagnose tumors more precisely and treat cancer patients more successfully. The DKFZ's Cancer Information Service (KID) provides patients, interested citizens and experts with individual answers to questions relating to cancer.
To transfer promising approaches from cancer research to the clinic and thus improve the prognosis of cancer patients, the DKFZ cooperates with excellent research institutions and university hospitals throughout Germany:
- National Center for Tumor Diseases (NCT, 6 sites)
- German Cancer Consortium (DKTK, 8 sites)
- Hopp Children's Cancer Center (KiTZ) Heidelberg
- Helmholtz Institute for Translational Oncology (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ
- DKFZ-Hector Cancer Institute at the University Medical Center Mannheim
- National Cancer Prevention Center (jointly with German Cancer Aid)
The DKFZ is 90 percent financed by the Federal Ministry of Education and Research and 10 percent by the state of Baden-Württemberg. The DKFZ is a member of the Helmholtz Association of German Research Centers.
