New evidence published by The BMJ today casts doubt on a much-hyped blood test for the NHS that promises to detect more than 50 types of cancer.
The test, called Galleri, has been hailed as a "ground-breaking and potentially life-saving advance" by its maker, the California biotech company Grail, and the NHS is currently running a £150m Grail-funded trial of the test involving more than 100,000 people in England, report Dr Margaret McCartney and investigative journalist Deborah Cohen.
NHS England claims the test can identify many cancers that "are difficult to diagnose early," such as head and neck, ovarian, and pancreatic cancers, and that if effective, could be used in a national screening programme.
Trial success would also hand Grail a lucrative deal with the NHS, which, if results are favourable, has agreed to buy millions of tests in exchange for a new state-of-the-art facility built by Grail in the UK. Although contract details remain confidential, a single test in the US currently retails for $950.
But documents leaked to The BMJ suggest that the trial is not suitable to justify a national screening test, while experts believe that Galleri has been over-hyped and that the current trial is unethical.
Even the chair of the UK National Screening Committee has privately voiced "serious concerns" to NHS England's chief executive about the trial, according to emails seen by The BMJ.
Interim results of the trial have not been published as expected this month. Instead, NHS England said the results were not "compelling enough" and a decision to roll out the test will wait until final trial results in 2026.
But as the trial continues, Freedom of Information requests by The BMJ raise further concerns over the close relationship between key government figures and Grail, including meetings with ex-prime minister Lord Cameron and Nadhim Zahawi, then minister in the Department for Business, Energy and Industrial Strategy.
