Reston, VA (March 21, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
Summaries of the newly published research articles are provided below.
Boosting Lymph Node Detection in Prostate Cancer
Accurate lymph node staging is critical in prostate cancer, yet 68Ga-PSMA-617 PET/CT alone has limitations. This study explores the potential of 68Ga-RM26 PET/CT, which targets a different receptor, to enhance detection. By combining both imaging techniques, researchers assess whether dual-target PET/CT improves sensitivity in identifying pelvic lymph node metastases.
Faster, Whole-Body Imaging for Cancer Treatment
Tracking radiation doses after cancer treatment is essential but time-consuming. This study tests a new high-speed CZT SPECT scanner against the conventional method, showing comparable accuracy with significantly shorter scan times. If widely adopted, this technology could make post-treatment monitoring quicker and more efficient for patients and doctors alike.
A New Approach to Testing Medical Imaging Tracers
Researchers have developed a new lab system that mimics real human tissue to test medical imaging tracers more accurately. This 3D cell culture method could reduce reliance on animal testing while improving how new radiotracers are evaluated for diagnosing and treating diseases like cancer, making medical research more efficient.
Smarter, Faster Radiation Dose Tracking
Doctors use imaging to track radiation therapy, but traditional methods require multiple scans over time. This study introduces a machine-learning approach to predict radiation dose effects from a single early scan, making the process quicker and more flexible. This innovation could improve patient care while simplifying cancer treatment monitoring.
A Smarter Approach to Prostate Cancer Treatment
New prostate cancer imaging and treatment agents aim to boost effectiveness while reducing side effects. This study introduces novel PSMA-targeted radioligands designed for better tumor targeting with lower risk to healthy tissues. Early results suggest they could improve both diagnosis and therapy, offering a more precise approach to patient care.
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