Reston, VA (April 4, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
Summaries of the newly published research articles are provided below.
A New Approach to Targeting Melanoma with Radiation Therapy
This study explores the use of 212Bi-labeled macroaggregated albumin (MAA) for treating mouse melanoma. It demonstrates that 212Bi-MAA effectively kills melanoma cells, inhibits tumor growth, and shows minimal toxicity. The research provides promising insights into the potential of α-particle radiation in targeted cancer therapies.
Enhancing Brain PET Imaging with a New Clustering Algorithm
A new supervised clustering algorithm (SVCA) offers an alternative to the traditional arterial input function in brain PET imaging. By improving the reliability and repeatability of PET scans targeting brain injury and repair, SVCA reduces variability, making PET analysis more accessible and accurate for clinical applications.
Validating an AI Network for Brain Tumor Imaging in Glioblastoma
An independent validation of an AI-based segmentation network for 18F-FET PET scans in glioblastoma patients shows strong correlation with physician assessments. While the automated system performed well, it slightly underestimated tumor volume and occasionally misidentified areas, suggesting the need for further training to enhance accuracy in clinical settings.
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