NUS Advances Boldly in Synthetic Biology Future

2024 10 Synbio ecosystem 1

2024 10 Synbio ecosystem 1
Prof Liu Bin (right), NUS Deputy President (Research and Technology), and Assoc Prof Matthew Chang (left), Director of NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), showcase products made from hybrid textiles incorporating monomers made using synthetic biology.

The National University of Singapore (NUS) will be taking a significant leap forward in synthetic biology, leveraging its deep expertise and cutting-edge innovations to usher a new paradigm for green manufacturing, driven by this rapidly evolving field. Over the next six years, the University plans to dedicate substantial resources and efforts - estimated to value around S$120 million - to firmly establish synthetic biology as a foundational pillar of NUS' innovation ecosystem, driving transformative benefits for Singapore across multiple sectors.

Traditionally, manufacturing is heavily dependent on petrochemicals, a major contributor to the climate crisis. However, synthetic biology (SynBio), enabling the design and engineering of biological 'factories' to create more efficient, sustainable processes and products, is emerging as a game-changer in driving the chemical industry towards a greener future. This groundbreaking approach has the potential to significantly reduce environmental impact, paving the way for greater sustainability across diverse sectors, including food, textiles, flavours, and fuels. This shift promises widespread positive effects, reshaping industries and advancing the global effort to combat climate change.

"NUS is charging ahead, pioneering efforts to strengthen and expand the University's synthetic biology ecosystem, positioning Singapore at the forefront of tackling global challenges such as food security, energy resilience, and sustainable development. We are deeply committed to surpassing previous accomplishments and achieving new heights of excellence in synthetic biology," said Professor Liu Bin, NUS Deputy President (Research and Technology).

She added, "A vibrant synthetic biology ecosystem in NUS and Singapore will foster new industry partnerships, cultivate a highly skilled workforce and inspire a wave of innovative startups. Together, these developments are poised to boost Singapore's economic growth."

2024 10 Synbio ecosystem 2

2024 10 Synbio ecosystem 2
Assoc Prof Matthew Chang (second from left) and his team at NUS SynCTI (from left), including Ms Zhang Chenxin, Dr Gazi Sakir Hossain and Dr He Yuanzhi, are driving research and innovation in the rapidly advancing field of synthetic biology.

A key driver of innovation in the University's SynBio ecosystem is the NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), which was established as early as 2014 when the field was still in its early stages.

Associate Professor Matthew Chang, Director of SynCTI, said, "Now is the time for synthetic biology to achieve a lasting, transformative impact. Over the past decade, NUS has developed robust capabilities and strategic networks, positioning both NUS and Singapore to seize emerging opportunities in this rapidly advancing field. We are eager to collaborate closely with our academic, research, and industry partners to foster ongoing growth, innovation, and the application of synthetic biology, both locally in Singapore and globally."

2024 10 Synbio ecosystem 3

2024 10 Synbio ecosystem 3
Assoc Prof Matthew Chang (middle) and researchers Dr Gazi Sakir Hossain (left) and Ms Zhang Chenxin (right) at NUS SynCTI's pilot-scale synthetic biology laboratory, which boasts advanced equipment such as a pilot-scale bioreactor used in bioprocessing which bridges the gap between laboratory-scale experiments and full-scale industrial production.

Embarking on new SynBio initiatives

NUS has launched several bold endeavours to realise the vision of a SynBio-driven future:

1. NUS is spearheading the establishment of Singapore's new national SynBio initiative to advance Singapore's biomanufacturing sector. This initiative will foster a whole-of-nation effort to galvanise the potential of SynBio in advancing green manufacturing practices. Please refer to Annexe 1

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