Major Collision Investigation Unit detectives are investigating the circumstances surrounding a fatal collision in Parwan this morning.
Emergency services were called to reports two cars collided on Nerowie Road between Parwan South Road and Bucklers Road about 10.10am.
The driver of one of the vehicles, who is yet to be formally identified, died at the scene.
The female passenger of that vehicle was taken to hospital with life-threatening injuries.
The rear passengers, two children, were also taken to hospital with non-life-threatening injuries.
The driver of the second vehicle has been arrested and is assisting police with their enquiries.
The circumstances surrounding the collision are yet to be established and the investigation is ongoing.
Anyone with dashcam footage or information is urged to contact Crime Stoppers on 1800 333 000 or make a report online at www.crimestoppersvic.com.au