About 5.20am today (Sunday 27 February 2022), emergency services were called to the Golden Highway, Cassilis, in the Upper Hunter, after reports two trucks were involved in a head-on collision.
The male driver of one of the trucks died at the scene and is yet to be formally identified.
Officers from The Hunter Valley Police District established a crime scene, which will be examined by specialist forensic police.
An investigation into the crash is underway and a report will be prepared for the information of the Coroner.
The Highway is closed in both directions.
Motorists are urged to avoid the area as delays are expected.
As inquiries continue, anyone who may have witnessed or has dashcam footage of the crash, are urged to contact Crime Stoppers on 1800 333 000.