Wyndham Crime Investigation Unit detectives have arrested five men after an alleged pursuit through multiple northern suburbs overnight.
Police observed a white Toyota Camry allegedly driving at high speed west bound on Paisley Street in Footscray about 11.40pm on Friday, 7 June.
With assistance from the Air Wing, the Toyota was alleged to have been observed travelling at speeds of 150km/hr throughout Footscray, Derrimut, Sunshine, Moonee Ponds and Brunswick.
Officers successfully deployed stop sicks on Sydney Road and the car came to a halt on the overpass above the Tullamarine Freeway, Parkville about 00.20am.
All five occupants inside the vehicle were swiftly arrested and are currently assisting police with their enquiries.
It is not believed the Toyota is stolen.
Anyone who witnessed the incident, has CCTV/dashcam footage or information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppers.com.au