Police are investigating the circumstances surrounding the death of a man in North Melbourne on Friday.
Officers attended Langford Street, North Melbourne about 4.20pm after receiving reports of a man causing trouble in the vicinity of Macaulay Railway Station.
A man was located on the ground in the street and was acting erratically.
He was taken into custody by police so appropriate medical treatment could be obtained.
The man's health deteriorated whilst police were waiting for an ambulance and first aid was given by officers.
Ambulance crews arrived a short time later and treated the 27-year-old man of no fixed address, but he died at the scene.
Detectives from the Homicide Squad will investigate the incident with oversight from Professional Standards Command, as per standard practice when a person dies in police custody.