Yarra Ranges Highway Patrol are investigating following a single vehicle crash in Millgrove last night.
Investigators have been told a white Toyota Tarago was travelling south-west on Dee Road when it is believed the driver veered off the road and struck a tree about 10.30pm.
The driver and front seat passengers, both men, were airlifted to hospital with life-threatening injuries.
Four other people, three men and a woman were taken to hospital by road with non-life-threatening injuries.
The exact cause of the crash is yet to be determined and the investigation remains ongoing.
Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au
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