Major Collision Investigation Unit detectives are investigating a fatal collision in Mortlake yesterday afternoon.
Emergency services were called to reports a silver Toyota Hilux utility and a grey Holden Barina collided at the intersection of Castle Carey and Mortlake-Ararat roads about 4pm.
The driver of the Holden, a 32-year-old Warrnambool man, died at the scene.
The driver of the Toyota, a 26-year-old Penshurst man, sustained serious injuries and was taken to hospital.
The exact circumstances surrounding the collision are yet to be determined and investigations remain ongoing.
Anyone who witnessed the collision, has CCTV, dashcam footage or any other information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au