Major Collision Investigation Unit detectives are investigating a multi-vehicle collision in Pine Lodge on Friday.
It is alleged a Toyota Camry failed to stop at a stop sign and collided with a Toyota Orien and a Mazda wagon at the intersection of New Dookie and Boundary roads about 6.20pm.
Six people were transported to hospital with injuries.
Of those, a 17-year-old female passenger and a 32-year-old male passenger remain in hospital in a critical condition.
The driver of the Camry, a 30-year-old Kialla man, also remains in hospital.
The investigation into the circumstances of the collision remain ongoing.
Quotes attributable to Detective Sergeant Lee Barton, Major Collision Investigation Unit:
"Victoria Police again appeal to all members of the community to drive with care. Last year saw numerous serious collisions across rural locations that could have been avoided by drivers simply slowing down and paying greater attention to the roadway and relevant signs - it's the drivers responsibility," he said.
"These collisions have a lifelong effect on those unfortunately involved and their families that are left to care or grieve."
Anyone who witnessed the incident or has dashcam/CCTV footage are urged to contact Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au.
