The Brisbane Valley Highway at Wivenhoe Pocket is closed between Wivenhoe Dam and Fernvale due to a serious single truck crash that happened today.
Around 3.40am a truck has overturned after it left the highway and hit a number trees.
Two men are trapped in the truck and are believed to have serious injuries.
The road between Wivenhoe Pocket and Fernvale will be closed most of the day, and motorists are advised to take a detour through Lowood.
The Forensic Crash Unit attended the location and are conducting investigations into the crash.
Investigators are seeking anyone who witnessed the incident or who may have dash cam to contact the police.
If you have information for police, contact Policelink on 131 444 or provide information using the online form 24hrs per day.
You can report information about crime anonymously to Crime Stoppers, a registered charity and community volunteer organisation, by calling 1800 333 000 or via crimestoppersqld.com.au 24hrs per day.