Police are appealing for public assistance to help locate missing Doveton man Ronald.
The 54-year-old was last seen at the corner of Bourke Street and Swanston Street in the Melbourne CBD about 1.15pm on Saturday, 22 February.
Police and family have concerns for Ronald's welfare as he has a number of serious medical conditions including autism.
Ronald is also non-verbal and has recently undergone abdominal surgery.
Ronald is Caucasian, about 165cm tall with light brown/grey hair, blue eyes, has a mark on his chin and walks with a lean to his left side.
He was last seen wearing a grey polo shirt with white around the collar, a white singlet, black track pants, black shoes and black sunglasses with orange-tinted lenses.
Ronald was also carrying a soup spoon at the time of his disappearance.
It is possible that Ronald may be travelling on public transport.
Investigators have released an image of Ronald in the hope that someone recognises him and can provide information as to his whereabouts.
Anyone who sees Ronald is urged to contact Triple Zero (000) immediately.
Anyone with other information that could assist police in locating him is urged to contact Crime Stoppers on 1800 333 000.