Police are appealing for public assistance to help locate missing girl Chloe.
The 15-year-old was last seen in Upper Ferntree Gully last night about 7.30pm.
Police and family have concerns for her welfare due to a medical condition.
Chloe is described as being Caucasian in appearance, about 165cm tall, with a slim build and blonde hair.
She was last seen wearing a black hoodie, black track pants and black shoes with red soles.
Chloe may have been seen at a supermarket on the Burwood Highway about 8pm.
She is known to travel on public transport in the Ferntree Gully and Knox areas.
Police have released an image of Chloe in the hope someone can provide information on her current whereabouts.
Anyone with information is urged to contact Belgrave Police Station on (03) 9754 6677.