Police are currently searching and appeal for public assistance to help locate missing Point Cook woman Samantha.
Police have been told the 33-year-old's grey Kia Sportage broke down on the Princes Highway in Tamboon about 8.15am on Friday 26 April.
It is believed a passer-by stopped to assist Samantha and she has not been seen since.
Police and family have concerns for Samantha's welfare due to a medical condition and it is out of character.
Samantha was last seen wearing blue/grey fleece top, jeans and runners.
Investigators believe Samantha was attempting to travel to Melbourne and may have been hitchhiking along the Princes Highway.
Police have released images of Samantha in the hope that someone can provide information on her current whereabouts.
Anyone who sights Samantha is urged to contact Lakes Entrance Police Station on (03) 5155 1206.