www.cdc.gov/nchs/fastats/leading-causes-of-death.htm">stroke in the United States, and it is the fifth leading cause of death and the most common cause of permanent disability. More than 80% of strokes are ischemic strokes, most often caused by narrowing or a blockage in the carotid arteries in the neck - the primary blood vessels that supply blood to the brain - restricting blood flow to the brain. While carotid endarterectomy, a surgical procedure to remove plaque from the carotid artery, has been shown to reduce the risk of stroke, not all patients experience the same outcomes, according to a new study led by researchers from the Penn State College of Medicine.
The team analyzed findings from previously published studies over the last 25 years and found that compared to white patients, non-white patients are at twice the risk of dying within 30 days of a carotid endarterectomy. The study highlights persistent differences in medical outcomes based on race, despite advances in research, education and clinical practice.
The findings were published in the Journal of Vascular Surgery. According to the researchers, the study is the first meta-analysis - meaning it examines data from previously published studies - to determine the influence of race on carotid endarterectomy outcomes and, with data from over half a million patients, it's one of the largest studies within the carotid artery surgery research literature.
"Twice the risk is a big risk," said Ahsan Zil-E-Ali, research fellow in the Heart and Vascular Institute at the Penn State College of Medicine and first author of the study. "The fact that this increased risk is the same throughout the studies over the years surprised our group. Why are we not able to fix this problem?"
Health disparities are preventable differences in health outcomes between groups that stem from social and economic inequities. Disparities can refer to measures like life expectancy, the prevalence of a disease or condition and health status.
Carotid endarterectomy is a frequently performed and well-studied procedure. Disparities in surgical outcomes for the procedure were first reported approximately 30 years ago, explained Zil-E-Ali. The research team was interested in answering two primary questions - how has the risk of mortality and stroke after carotid endarterectomy changed over time and how does the risk compare between white and non-white patient populations?
