Pete Williams is one of few researchers in Sweden concentrating on glaukoma. The goal is an effective treatment, something that stops the degenerative process in the nerve cells of the eye.
Pete Williams is the senior author of a new paper in Nature Communications on how deficiency of the enzyme NMNAT2 renders the nerve cells of the eye vulnerable to neurodegeneration and could be a key in the search for a treatment.
Glaucoma is very common. Eighty million people worldwide have the eye disease (an estimated 100-200,000 in Sweden alone). There is no cure, but there are treatments that lower the pressure in the eye and that can slow down the progression of the disease, which otherwise leads to irreversible blindness.
Not always treatable
"Most people who have heard of glaucoma believe that it can be treated with eye drops and surgery. Unfortunately, this is not entirely true. For many of the patients, the treatment lower the eye pressure but doesn't prevent furthervision loss," says Pete Williams.
Knowledge about glaucoma has taken time to develop because the disease progresses slowly. This means that in the past, it took many years before researchers could see if a particular treatment had any effect. However, in the last decade or so, the availability of instruments that measure changes in the eye much earlier than the patient experiences them has given new impetus to research into the eye disease.
The importance of NAD
In the 1980s, research into neurodegenerative diseases discovered a link with NAD, a co-enzyme, i.e. a molecule that binds to an enzyme and makes it active. Pete Williams' group was the first to show that NAD levels were low in animal models of glaucoma.
"NAD has many important functions in the body. A lack of it is important for neuronal health and survival in many diseases, but we don't yet know how to use this information to create a better treatment " says Pete Williams.
When the body makes NAD, it uses an enzyme NMNAT1. However, in neurons, it needs another enzyme: NMNAT2 (which is only found in neurons).
"In our recent paper in Nature Communications, we show that NMNAT2 is needed to protect neurons in the eye and that gene therapy can be used to increase levels," says Pete Willams. "
The research team is now moving on to try to develop new substances that target NMNAT2 in nerve cells.
- We believe these compounds could be a starting point for future glaucoma treatment.
Publication
NMNAT2 is a druggable target to driveneuronal NAD production James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalaki, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams. Nature Communications, online 24 Julyb2024. doi: 10.1038/s41467-024-50354-5
