A second person has died following a collision in Allans Flat on 10 July.
It is understood a grey Ford Falcon sedan collided with a utility towing a trailer on Wodonga-Yackandandah Road around 2pm.
The utility left the road and crashed down an embankment.
The driver of the Ford Falcon, an 18-year-old West Wodonga man, died at the scene.
The passenger of the Ford, a 17-year-old Myrtleford girl, was airlifted with life-threatening injuries but has died in hospital.
The driver of the utility, a 58-year-old West Wodonga woman, was taken to hospital in a critical condition.
The passenger, a 19-year-old Allans Flat man, was taken to hospital with non-life-threatening injuries.
Major Collision Investigation Unit detectives are investigating the exact circumstances surrounding the collision.
Anyone who witnessed the collision, has CCTV, dashcam footage or any other information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au