The man was reported to have gone into the water through the space between a moored cargo vessel and the quayside. It happened on the east bank in the hour between about midnight and 1am on 23 June 2024.
The incident was attended by Hunstanton and Sutton Bridge Coastguard Rescue Teams as well as Cambridgeshire Police and Cambridgeshire Fire and Rescue Service.
Lesley Hopker, from the MCA's Regulatory Compliance Investigations Team, said:
This was a tragic incident in which a man lost his life. We're hoping someone may remember hearing or seeing anything unusual to help us learn more about what happened.
The location was on the east bank of the River Nene, not far from the entrance to Port of Wisbech on Nene Parade, opposite properties on West Parade on the west bank.
We're appealing to anyone who saw the incident, has video footage or still images, or has any other relevant information that might help to please